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The active ingredient in Renagel Tablets is sevelamer hydrochloridea polymeric amine that binds phosphate and is meant for oral administrationSevelamer hydrochloride is poly(allylamine hydrochloridecrosslinked with epichlorohydrin in which forty percent of the amines are protonatedIt is known chemically as poly(allylamine-co-N,Ndiallyl-1,3-diamino2-hydroxypropanehydrochlorideSevelamer hydrochloride is hydrophilicbut insoluble in waterThe structure is represented in Figure 1.

Renagel must not be used in people with hypophosphataemialow blood phosphate levelsor with bowel obstructiona blockage in the gut

PregnancyNot absorbed systemically following oral administration and maternal use not expected to result in fetal exposure to the drug.

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